Fertility future with testicular cryopreservation

Fertility preservation is now a reality for male pediatric and adolescent/young adult (AYA) patients with cancer or blood disorders.

The Hyundai Cancer Institute at CHOC Children’s is a center of excellence and the only program on the West Coast offering testicular preservation for prepubertal patients unable to bank sperm. Testicular tissue is biopsied and preserved in liquid nitrogen.

“Recent research indicates these biopsies contain stem cells, leading to the possibility of generating sperm in the future,” said Dr. Carol Lin, a pediatric oncologist at the CHOC Hyundai Cancer Institute.

Evidence-based research

CHOC participated in an eight-year study alongside U.S. and Israeli institutions to establish a standardized protocol and centralized process to freeze and collect biopsies.

A CHOC Children's pediatric urologist speaks with an adolescent male patient in an exam room

“In total, 189 patients provided samples. A quarter of each sample was used for research and the rest stored for future use. These patients ranged from ages 5 months to 34, with an average age of about 8,” said Lin.

The study discovered that a centralized process and testicular biopsies from multiple sites was a viable option and could accelerate recruitment. Click here to learn more about the study.

Sharing expertise

CHOC is a member of the Oncofertility Consortium, a group of scientists and providers who are committed to fertility preservation in cancer patients. The consortium studies the science of cryopreservation methods, storage of tissue, in vitro follicle growth and communication between patients and doctors, as well as ethical and legal concerns.

Our care and commitment to children has been recognized

CHOC Children’s Hospital was named one of the nation’s best children’s hospitals by U.S. News & World Report in its 2020-21 Best Children’s Hospitals rankings and ranked in the cancer specialty.

Best Children's Hospitals, U.S. News & World Report, Cancer, 2020-21

Learn how CHOC’s pediatric oncology treatments, expertise and support programs preserve childhood for children in Orange County, Calif., and beyond.

Bringing Fertility Preservation to the Forefront of Cancer Treatment

Efforts by the Hyundai Cancer Institute at CHOC Children’s to ensure fertility preservation is top of Oncofertilitymind for adolescent and young adult oncology patients, as well as their care providers, were recently profiled by The Huffington Post.

“It is a fundamental right of any individual to be offered fertility preservation,” Dr. Leonard Sender, medical director of the Cancer Institute told the online news site. “If we, as a society, believe in cancer survivorship, then what we need is for people to have a choice as to if they want to have children or not.”

Earlier this year, Dr. Sender co-hosted a workshop on oncofertility at Stupid Cancer’s CancerCon. The goal was to bring together leading experts on fertility preservation to discuss the need and path forward to make fertility preservation a topic of conversation with every AYA oncology patient undergoing treatment at every pediatric hospital in the country.

Read the full article in The Huffington Post.